Objective : To investigate vasculogenic mimicry (VM) in Kazakh patients with esophageal squamous cell carcinoma (ESCC), as well as its association with p53 expression and its influence on prognosis. Methods : A total of 76 Kazakh patients with ESCC who underwent thoracic surgery at the First Affiliated Hospital of Xinjiang Medical University between December 2010 and November 2015 were enrolled in the present study. CD34-PAS double staining combined with hematoxylin and eosin staining was used to detect VM patterns in 76 patients with ESCC and 20 patients with adjacent normal tissue. Results : VM was observed in 42.1% (32/76) of the Kazakh EC tissues. Both VM incidence and P53 expression were significantly associated with the degree of tumor differentiation (P <0.001). The survival rate of patients with EC with VM was significantly lower than that of patients without VM (log rank test, c2 =7.803; P <0.05). However, there was no significant correlation between the expression of p53 and survival (log rank test, c2=0.447; P =0.504). Conclusion: The present study demonstrated that VM occurs in the EC of Kazakh individuals and coexists with endothelium-dependent blood vessels. There is a synergistic effect between angiogenesis mimicry and mutant p53 in the malignant progression of EC, which is associated with the poor prognosis of patients with EC.

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