[1] Yang Wen Xian, Wang Rui Lin, Liu Gui Ting, et al. Fifty Years’ retrospection of review on strategies and countermeasures for esophageal cancer prevention and control in Linzhou, Henan Province[J]. China Cancer, 2010, 19(1): 15-17
[2] Qiu Song Liang. The Path of Discovery: A pathologist's review[J]. China Cancer, 2008, 17(6): 463-464
[3] Henan Medical College. Esophageal Cancer[M]. Beijing: People's Medical Publishing House, 1982
[4] Du Bai Lian, Ed. Esophageal Cancer[M], Beijing: China Science and Technology Press, 1994
[5] Wang LD, Shi ST, Zhou Q, et al. Changes in p53 and cyclin D1 protein levels and cell proliferation in different stages of human esophageal and gastric-cardia carcinogenesis[J]. Int J Cancer, 1994, 59(4): 514
[6] Wang LD, Song X, Zhao XK, et al. Molecular basis and precision medicine for interactions of genetic and environmental risk factors in esophageal cancer[J]. Chin J Clin Oncol, 2016, 43(12): 515-520
[7] Yang ZH, Hao JS. Zhou Enlai was concerned about the prevention and control of endemic diseases, the construction of the Red Flag Canal and the growth of cadres in Linxian[J]. Party documents, 1998,1: 37
[8] Esophageal Cancer Research Collaboration Group of Henan. Diagnosis and surgical treatment of early esophageal cancer[J]. National Medical Journal of China, 1975, 1:340
[9] Cancer Prevention and Treatment Research Team of Henan Province, Esophageal Cancer Etiology Research Group of Henan Medical College. Study on the relationship between mold and esophageal cancer (1) Preliminary observation of esophageal cancer induced by moldy food in rats; 2. Experimental observation on synergistic carcinogenesis of moldy food and nitrosamines)[J]. Cancer Research and Prevention and Treatment, 1975, 3: 19-25
[10] Esophageal Cancer Research Collaboration Group of Henan. Early diagnosis and surgical treatment of esophageal cancer in rural areas[J]. National Medical Journal of China, 1975, 12: 845
[11] Esophageal Cancer Research Collaboration Group of Henan. Pathological study of early esophageal cancer[J]. Chinese Medical Journal, 1977, 3: 180
[12] Esophageal Cancer Research Collaboration Group of Henan. Pathological of early esophageal cancer[J]. Chinese Medical Journal, 1977, 3(3): 184
[13] Qiu SL. Observation of the epithelium adjacent to esophageal squamous cell carcinoma[J]. Chin J Pathol, 1964, 3:186
[14] Shen Q. A preliminary analysis of clinical pathology of esophagitis in Linxian, Henan province. Chin J Pathol, 1965: 407
[15] Shao LF. Animal experiment and clinical application of esophagogastric anastomosis device[C]. The abstract of the 9th National surgical academic conference, Chinese Medical Association, 1978: 247
[16] Qiu SL. The precancerous of esophageal cancer[J]. Chinese Journal of Oncology, 1980, 2(1): 79
[17] Shen Q, Shu YJ. Cytology as a screening method for esophageal carcinoma in the People’s Republic of China[M]// Pfeiffer CJ. Cancer of the esophagus. Boca Raton: CRC Press, 1982, 11:3
[18] Shen Q. Diagnostic cytology and early detection[M]//HUANG GJ, WU YK. Carcinoma of the esophagus and gastric cardia. Berlink: Springer Press,1984:155
[19] Shen Q, Liu SF, Dawsey SM, et al. Cytologic screening for esophageal cancer: results from 12,877 subjects from a high-risk population in China[J]. Int J Cancer, 1993, 54: 185
[20] Wahrendorf J, Chang-Claude J, Qiu SL, et al. Precursor lesions of oesophageal cancer in young people in a high-risk population in China[J]. Lancet, 1989, 2(8674): 1239
[21] Chang-Claude JC, Wahrendorf J, Qiu SL, et al. An epidemiological study of precursor lesions of esophageal cancer among young persons in a high-risk population in Huixian, China[J]. Cancer Res, 1990, 50(8): 2268
[22] Qiu SL, Yang GR. Precursor lesions of esophageal cancer in high-risk populations in Henan Province, China[J]. Cancer, 1988, 62(3): 551
[23] Shen Q, Qiu SL, Zhao HZ, et al. Esophageal cytology research[J]. Journal of Zhengzhou University (Medical Sciences), 1964, 3:1
[24] Wang LD, Lipkin M, Qui SL, et al. Labeling index and labeling distribution of cells in esophageal epithelium of individuals at increased risk for esophageal cancer in Huixian, China[J]. Cancer Res, 1990, 50(9): 2651
[25] Yang WX, Lu SX, Liu GT, et al. Study on establishing strategies and measures of esophageal cancer prevention and control in high-risk areas of China[C]. A collection of essays of the Academic Seminar of the Chinese Association for Science and Technology, 2011: 155-159
[26] Wang LD, Zheng S. Esophageal cancer research: Historical review and its reflect on philosophy[J]. Medicine and philosophy, 2001, 22(9): 1-5
[27] Wang JZ. The period as a medical worker in Linxian[J]. The window for anti-cancer, 2006, 4: 34-35
[28] Zhang XD. The story behind the red flag canal - an interview with Yang Gui, former county secretary of Linxian, Henan Province[J]. The window for anti-cancer, 2006, 4: 30-33
[29] Li B. A Review of Cancer Prevention and Control in New China[J]. Jianghuai literature and history, 1998,1: 97-111
[30] Yang CS. Research on esophageal cancer in China: a review[J]. Cancer Res, 1980, 40(8 Pt 1): 2633
[31] Chang-Claude J, Becher H, Blettner M, et al. Familial aggregation of oesophageal cancer in a high incidence area in China[J]. Int J Epidemiol, 1997, 26(6): 1159
[32] Yu Y, Taylor PR, Li JY, et al. Retrospective cohort study of risk-factors for esophageal cancer in Linxian, People's Republic of China[J]. Cancer Causes Control, 1993, 4(3): 195
[33] Liu FS, Dawsey SM, Wang GQ, et al. Correlation of epithelial proliferation and squamous esophageal histology in 1185 biopsies from Linxian, China[J]. Int J Cancer, 1993, 55(4): 577
[34] Dawsey SM, Wang GQ, Weinstein WM, et al. Squamous dysplasia and early esophageal cancer in the Linxian region of China: distinctive endoscopic lesions[J]. Gastroenterology, 1993, 105(5): 1333
[35] Dawsey SM, Wang GQ, Taylor PR, et al. Effects of vitamin/mineral supplementation on the prevalence of histological dysplasia and early cancer of the esophagus and stomach: results from the Dysplasia Trial in Linxian, China[J]. Cancer Epidemiol Biomarkers Prev, 1994, 3(2):167
[36] Ku JW, Zhang DY, Song X, et al. Characterization of tissue chromogranin A (CgA) immunostaining and clinicohistopathological changes for the 125 Chinese patients with primary small cell carcinoma of the esophagus[J]. Dis Esophagus, 2017, 30(8): 1-7
[37] Li XM, Song X, Zhao XK, et al. The alterations of cytokeratin and vimentin protein expressions in primary esophageal spindle cell carcinoma[J]. BMC Cancer. 2018, 18(1): 356
[38] Wang LD, Zhou FY, Li XM, et al. Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54[J]. Nat Genet, 2010, 42(9): 759-763
[39] Wu C, Wang Z, Song X, et al. Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations[J]. Nat Genet, 2014, 46(9): 1001-1006
[40] Hu N, Wang Z, Song X, et al. Genome-wide association study of gastric adenocarcinoma in Asia: a comparison of associations between cardia and non-cardia tumours[J]. Gut, 2016, 65(10): 1611-1618
[41] hang P, Xia JH, Zhu J, et al. High-throughput screening of prostate cancer risk loci by single nucleotide polymorphisms sequencing[J]. Nat Commun, 2018, 9(1): 2022
[42] Agrawal N, Jiao Y, Bettegowda C, et al. Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma[J]. Cancer Discov, 2012, 2(10): 899-905
[43] Gao S, Li S, Ma Z, et al. Presence of Porphyromonas gingivalis in esophagus and its association with the clinicopathological characteristics and survival in patients with esophageal cancer[J]. Infect Agent Cancer, 2016, 19(11): 3
[44] Abnet CC, Freedman ND, Hu N, et al. A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma[J]. Nat Genet, 2010, 42(9): 764-767
[45] Wu C, Hu Z, He Z, et al. Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations[J]. Nat Genet, 2011, 43(7): 679-684
[46] Wang LD, Bi X, Song X,, et al. A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis[J]. Mol Carcinog, 2013, 52(Suppl1): E80-86
[47] Zhai S, Liu C, Zhang L, et al. PLCE1 promotes esophageal cancer cell progression by maintaining the transcriptional activity of snail[J]. Neoplasia, 2017, 19(3): 154-164
[48] Shen Q, Wang DY, Cai XS, et al. Evaluation of compound riboflavin in the intervention treatment of esophageal dysplasia. Chinese Journal of Clinical Oncology, 1997, 24(5): 331-334
[49] Cao W, Shen Q, Yang WX, et al. Animal experimental study on the antineoplastic effect of compound riboflavin against nitrosamines[J]. Henan Journal of Oncology, 1996, 9(2): 88-91
[50] Shen Q, Wang DY, Xiang YY, et al. A Report on the Treatment of Esophageal Premalignant Hyperplasia with Combined Riboflavin Blockade. Chinese Journal of Clinical Oncology, 1994, 21(4): 250-251
[51] Huang M, Lin Y, Wang Q, et al. The effect of combined riboflavin on the transformation of esophageal premalignant hyperplasia[J]. Journal of Henan Medical University, 1991, 26(4): 334-337
[52] Shen Q, Zheng HZ, Cai XS, et al. Analysis of 12-year Results of Pyridoxine Prophylaxis in the Treatment of Severe Epithelial Proliferation in the Esophagus[J]. Henan Journal of Oncology, 1991, 4(1): 1-5
[53] He Y, Ye L, Shan B, et al. Effect of riboflavin-fortified salt nutrition intervention on esophageal squamous cell carcinoma in a high incidence area, China[J]. Asian Pac J Cancer Prev, 2009, 10(4): 619-622
[54] Wang LD, Guo RF, Fan ZM, et al. Association of methylenetetrahydrofolate reductase and thymidylate synthase promoter polymorphisms with genetic susceptibility to esophageal and cardia cancer in a Chinese high-risk population[J]. Dis Esophagus, 2005, 18(3): 177-184
[55] Wang Y, Fang MZ, Liao J, et al. Hypermethylation-associated inactivation of retinoic Acid receptor Beta in human esophageal squamous cell carcinoma[J]. Clin Cancer Res, 2003, 9(14): 5257-5263
[56] Deng C, Xie D, Capasso H, et al. Genetic polymorphism of human O6-alkylguanine-DNA alkyltransferase: identification of a missense variation in the active site region[J]. Pharmaco-genetics, 1999, 9(1): 81-87
[57] Song Y, Li L, Ou Y, et al. Identification of genomic alterations in oesophageal squamous cell cancer[J]. Nature, 2014, 509(7498): 91-95
[58] Gao YB, Chen ZL, Li JG, et al. Genetic landscape of esophageal squamous cell carcinoma[J]. Nat Genet, 2014, 46(10): 1097-1102
[59] Lin DC, Hao JJ, Nagata Y, et al. Genomic and molecular characterization of esophageal squamous cell carcinoma[J]. Nat Genet, 2014, 46(5): 467-473
[60] Wang LD, Hong JY, Qiu SL, et al. Accumulation of p53 protein in human esophageal precancerous lesions: a possible early biomarker for carcinogenesis[J]. Cancer Res, 1993, 53(8): 1783-1787
[61] Wang LD, Zhou Q, Hong JY, et al. P53 protein accumulation and gene mutations in multifocal esophageal precancerous lesions from symptom free subjects in a high incidence area for esophageal carcinoma in Henan, China[J]. Cancer, 1996, 77(7): 1244-1249
[62] Xing EP, Nie Y, Song Y, et al. Mechanisms of inactivation of p14ARF, p15INK4b and p16INK4a genes in human esophageal squamous cell carcinoma[J]. Clin Cancer Res, 1999, 5(10): 2704 -2713
[63] Gao H, Wang LD, Zhou Q, et al. p53 tumor suppressor gene mutation in early esophageal precancerous lesions and carcinoma among high-risk populations in Henan, China[J]. Cancer Res, 1994, 54(16): 4342-4346
[64] Shi ST, Feng B, Yang GY, et al. Immunohistoselective sequencing (IHSS) of p53 tumor suppressor gene in human oesophageal precancerous lesions[J]. Carcinogenesis, 1996, 17(10): 2131-2136
[65] Yang G, Zhang Z, Liao J, et al. Immunohistochemical studies on Waf1p21, p16, pRb, and p53 in human esophageal carcinomas and neighboring epithelia from a high-risk area in northern China[J]. Int J Cancer, 1997, 72(5): 746-751
[66] Wang LD, Zhou Q, Yang WC, et al. Apoptosis and cell proliferation in esophageal precancerous and cancerous lesions: study of a high-risk population in Northern China[J]. Anticancer Res, 1999, 19(1A): 369-374
[67] Xing EP, Nie Y, Wang LD, et al. Aberrant methylation of P16ink4a and deletion of P15ink4b are frequent events in human esophageal cancer in Linxian, China[J]. Carcinogenesis, 1999, 20(1): 77-84
[68] Qi Y, Chiu JF, Wang L D, et al. Comparative proteomic analysis of esophageal squamous cell carcinoma[J]. Proteomics, 2005, 5(11): 2960-2971
[69] Xu YW, Peng YH, Chen B, et al. Autoantibodies as potential biomarkers for the early detection of esophageal squamous cell carcinoma[J]. Am J Gastroenterol, 2014, 109(1): 36-45
[70] Zhou SL, Yue WB, Fan ZM, et al. Autoantibody detection to tumor-associated antigens of P53, IMP1, P16, cyclin B1, P62, C-myc, Survivn, and Koc for the screening of high-risk subjects and early detection of esophageal squamous cell carcinoma[J]. Dis Esophagus, 2014, 27(8): 790-797
[71] Zhou SL, Ku JW, Fan ZM, et al. Detection of autoantibodies to a panel of tumor-associated antigens for the diagnosis values of gastric cardia adenocarcinoma[J]. Dis Esophagus, 2015, 28(4): 371-379
[72] Yang CS. Nutrition and Cancer[J]. Henan Pharmaceuticals, 1981, 1: 32-33.
[73] Qiu SL, Yang GR, Zhao LQ, et al. Precancerous lesions of esophagus in young people in the high-incidence areas of esophageal cancer[J], 1991, 4(1): 6-12
[74] Qiu SL, Yang GR, Zhao LQ, et al. The relationship between esophagitis in young people in high-risk areas for esophageal cancer and serum retinol and vitamin C levels[A]. Abstracts of the Academic Conference on Nutrition and Cancer of the Chinese Nutrition Society. 1990, 1: 85
[75] Norton JG, Frank GM. Year book of digestive diseases[M]. USA: Mosby,1997:35
[76] China Science and Technology Communication[R]. Ministry of Science and Technology of the People's Republic of China, Beijing: 2010, 593: 2
[77] He J Editor-in-Chief. China Medical Science and Technology Development Report[M]. Beijing: Science Press, 2011: 18
[78] Abnet CC, Wang Z, Song X, et al. Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: A meta-analysis of genome-wide association studies[J]. Hum Mol Genet, 2012,21(9):2132-2141
[79] Ma S, Bao JYJ, Kwan PS, et al. Identification of PTK6, via RNA sequencing analysis, as a suppressor of esophageal squamous cell carcinoma[J]. Gastroenterology. 2012,143(3):675-686
[80] Kong KL, Kwong DL, Chan TH, et al. MicroRNA-375 inhibits tumour growth and metastasis in oesophageal squamous cell carcinoma through repressing insulin-like growth factor 1 receptor[J]. Gut, 2012,61(1):33-42
[81] Wu C, Wang Z, Song X, et al. Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations[J]. Nat Genet, 2014, 46: 1001-1006
[82] Li Y, Fu L, Li JB, et al. Increased expression of EIF5A2, via hypoxia or gene amplification, contributes to metastasis and angiogenesis of esophageal squamous cell carcinoma[J]. Gastroenterology,2014,146(7):1701-1713
[83] Hu N, Wang Z, Song X, et al. Genome-wide association study of gastric adenocarcinoma in Asia: a comparison of associations between cardia and non-cardia tumours[J]. Gut,2016, 65(10):1611-1618
[84] Ming XY, Fu L, Zhang LY, et al. Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma[J]. Nat Commun, 2016,7:13568
[85] Sun HB, Li Y, Liu XB, et al. Early Oral Feeding Following McKeown Minimally Invasive Esophagectomy: An Open-label, Randomized, Controlled, Noninferiority Trial[J]. Ann Surg. 2018,267(3):435
[86] Zhang B, Zhang Z, Li L, et al. TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-κB signaling[J]. Nat Commun,2018,9(1):1423
[87] Zhao XK, Xing P, Song X, et al. Focal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma. Nat Commun. 2021, 12(1): 6489.
[88] Lu Z, Ren Y, Yang L, et al. Inhibiting autophagy enhances sulforaphane-induced apoptosis via targeting NRF2 in esophageal squamous cell carcinoma[J]. Acta Pharm Sin B. 2021, 11(5): 1246-1260.
[89] Liu F, Wu Q, Han W, et al. Targeting integrin αvβ3 with indomethacin inhibits patient-derived xenograft tumour growth and recurrence in oesophageal squamous cell carcinoma[J]. Clin Transl Med, 2021, 11(10): e548.
[90] Wang LD, Li LY, Song X, et al. Analysis of the histopathological types and clinicopathological features of primary esophageal malignant tumors in 272,437 patients[J]. Chin J Intern Med, 2022, 61(9): 1023-1030
[91] Liu X, Zhao S, Wang K, et al. Spatial transcriptomics analysis of esophageal squamous precancerous lesions and their progression to esophageal cancer. Nat Commun, 2023 , 14(1):4779.
[92] Jia R, Shan T, Zheng A, et al. Capecitabine or Capecitabine Plus Oxaliplatin Versus Fluorouracil Plus Cisplatin in Definitive Concurrent Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma (CRTCOESC): A Multicenter, Randomized, Open-Label, Phase 3 Trial. J Clin Oncol, 2024, 42(20): 2436-2445
[93] Wang LD, Du DF, Song X, et al. Study on the "environment-genetic-gene interaction" genomics of esophageal cancer: the interaction between riboflavin, RFT2, and NOTCH1-P53-Rb[J]. Journal of Zhengzhou University (Medical Sciences), 2018, 53(1): 1-5
[94] Wang LD, Zhou Q, Feng CW, et al. Intervention and follow-up on human esophageal precancerous lesions in Henan, northern China, a high-incidence area for esophageal cancer[J]. Gan To Kagaku Ryoho, 2002, 29(Suppl 1): 159-172
[95] Wang LD, Yang HH, Fan ZM, et al. Cytological screening and 15 years' follow-up (1986-2001) for early esophageal squamous cell carcinoma and precancerous lesions in a high-risk population in Anyang County, Henan Province, Northern China[J]. Cancer Detect Prev, 2005, 29(4):317-322
[96] Secrier M, Li X, de Silva N, et al. Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance[J]. Nat Genet, 2016, 48(10): 1131-1141
[97] Wang LD, Liu M, Hu YL, et al. Comparative analysis of clinicaopathological changes in esophageal cancer patients with ultra-long and short-term survival[J]. Cancer Res Prev Treat, 2014, 41(3): 193-198
[98] Hou ZC. The factors affecting the prognosis and cause of death of the early esophageal squamous cell carcinoma and the relationship between variations of rs1 and the different cancer stages[D]. Zhengzhou University, 2014
[99] Parasa S, Vennalaganti S, Gaddam S, et al. Development and validation of a model to determine risk of progression of Barrett's esophagus to neoplasia[J]. Gastroenterology, 2018, 154(5): 1282-128.